Enhanced endosomal escape for nanoparticle-enabled co-delivery of doxorubicin and siRNA to overcome multidrug resistance

Materials Today Advances · 2026 · 30:100845

Zhai J†, Surian A†, Cote T, Zhang W, Dang BT, Wang Y, Chen Q, Hoshino K, Lee J*, Chen Y*

Co-corresponding author

A Janus base nanoparticle platform for co-delivering doxorubicin and siRNA, evaluated in preclinical models of drug-resistant cancer.

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Citation

Zhai J†, Surian A†, Cote T, Zhang W, Dang BT, Wang Y, Chen Q, Hoshino K, Lee J*, Chen Y*. Enhanced endosomal escape for nanoparticle-enabled co-delivery of doxorubicin and siRNA to overcome multidrug resistance. Materials Today Advances. 2026;30:100845. doi:10.1016/j.mtadv.2026.100845.

† Equal contribution. * Corresponding author.

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